This report, co-authored by the organization now known as Education Cities and Public Impact, profiles three high-impact city-based organizations that are taking significant strides toward reforming their cities’ education systems: The Mind Trust in Indianapolis, New Schools for New Orleans, and The Skillman Foundation in Detroit. Through these organizations’ efforts, the report identifies a core set of lessons learned for leaders in other cities: (1) Find the right leader or leadership team; (2) Embrace strategies and theories of change that reflect local markets; (3) Develop a bold, comprehensive plan for reform; (4) Grow talent pipelines; (5) Support a strong, high-quality charter sector; (6) Invest in innovation; and, (7) Engage stakeholders in the community to accelerate reform.